Intravenous Gammaglobulin Treatment of Chronic
نویسندگان
چکیده
High-dose intravenous gammaglobulin (lVlgG) was given to 1 2 children and adults with chronic idiopathic thrombocytopenic purpura (ITP) to avoid splenectomy or because they either failed to respond to or required maintenance with high doses of steroids and/or immunosuppressives. The average platelet count increase to initial therapy was 239.5OO/ zl (range 23.000-790,000). A concomitant lgG Fc receptor blockade. measured by lgG-sensitized 51Crlabeled autologous erythrocytes. was seen in 1 1 of 11 patients tested. both splenectomized and not splenectomized. lasting 3-4 wk. Six or more months after treatment, 2 children are in remission, 2 children and 2 adults are
منابع مشابه
Intravenous gammaglobulin treatment in patients with hypogammaglobulinaemia.
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Intravenous infusion of gammaglobulin (IVGG) has been extensively used in the treatment of immune thrombocytopenic purpura (ITP) in adults to acutely raise the platelet count but not as a maintenance therapy. This report describes the maintenance treatment of adults with chronic ITP using repeated infusions of 800 to 1 .000 mg/kg of IVGG. Sixteen of 40 patients were able to discontinue all ther...
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High-dose intravenous gammaglobulin (lVlgG) was given to 1 2 children and adults with chronic idiopathic thrombocytopenic purpura (ITP) to avoid splenectomy or because they either failed to respond to or required maintenance with high doses of steroids and/or immunosuppressives. The average platelet count increase to initial therapy was 239.5OO/ zl (range 23.000-790,000). A concomitant lgG Fc r...
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Intravenous infusion of gammaglobulin (IVGG) has been extensively used in the treatment of immune thrombocytopenic purpura (ITP) in adults to acutely raise the platelet count but not as a maintenance therapy. This report describes the maintenance treatment of adults with chronic ITP using repeated infusions of 800 to 1,000 mg/kg of IVGG. Sixteen of 40 patients were able to discontinue all thera...
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